Nagelkerke, Nico J.D.De Vlas, Sake J.2014-07-312014-07-312003-02https://hdl.handle.net/10986/19152The potential epidemiological impact of preventive HIV vaccines on the HIV epidemic in Southern India is examined using a mathematical deterministic dynamic compartmental model. Various assumptions about the degree of protection offered by such a vaccine, the extent of immunological response of those vaccinated, and the duration of protection afforded are explored. Alternative targeting strategies for HIV vaccination are simulated and compared with the impact of conventional prevention interventions in high-risk groups and the general population. The impact of disinhibition (increased risk behavior due to the presence of a vaccine) is also considered. Vaccines that convey a high degree of protection in a share of or all of those immunized and that convey life-long immunity are the most effective in curbing the HIV epidemic. Vaccines that convey less than complete protection may also have substantial public health impact, but disinhibition can easily undo their effects and they should be used combined with conventional prevention efforts. Conventional interventions that target commercial sex workers and their clients to increase condom use can also be highly effective and can be implemented immediately, before the arrival of vaccines.en-USCC BY 3.0 IGOADULT MENADULT POPULATIONADULT PREVALENCEAIDS PATIENTSAIDS VACCINEASYMPTOMATIC INFECTIONSBEHAVIORAL RISKBIRTH RATECOMMERCIAL SEXCOMMERCIAL SEX WORKERCOMMERCIAL SEX WORKERSCONDOM PROMOTIONCONDOM USEDEATH RATEDRUG USEDRUGSEFFECTIVE VACCINESEPIDEMIOLOGICAL STUDIESFEMALE SEX WORKERSGAY MENHETEROSEXUAL TRANSMISSIONHIGH RISK GROUPSHIGH- RISKHIGH- RISK GROUPSHIGH-RISKHIGH-RISK BEHAVIORSHIGH-RISK GROUPSHIGH-RISK POPULATIONSHIVHIV INFECTIONHIV INFECTIONSHIV PREVALENCEHIV PREVENTIONHIV PREVENTION INTERVENTIONSHIV TESTHIV TRANSMISSIONHIV VACCINATIONHIV VIRUSIMMUNE RESPONSEIMMUNITYIMMUNIZATIONIMMUNOLOGYINTERVENTIONMALE CIRCUMCISIONMALE CLIENTSMOTHER-TO-CHILDMOTHER-TO-CHILD TRANSMISSIONNATIONAL AIDS CONTROLNEW INFECTIONSPATIENTSPREVENTION EFFORTSPREVENTION STRATEGIESPUBLIC HEALTHPUBLIC SERVICESRATES OF CONDOM USEREDUCTION IN TRANSMISSIONREDUNDANCYRISK BEHAVIORRISK POPULATIONSRISKY SEXSAFER SEXSEX WITH MENSEX WORKSEXUAL BEHAVIORSEXUAL BEHAVIORSSEXUAL PARTNERSSEXUALLY ACTIVESEXUALLY ACTIVE AGE GROUPSEXUALLY ACTIVE POPULATIONSEXUALLY TRANSMITTED DISEASESSEXUALLY TRANSMITTED INFECTIONSSTISSYNDROMIC TREATMENTUNPROTECTED SEXUNSAFE SEXUSE OF CONDOMSVACCINE PREVENTABLE DISEASESVACCINE RESEARCHVACCINESVERTICAL TRANSMISSIONVULNERABLE GROUPS ACQUIRED IMMUNE DEFICIENCY SYNDROMEHIV VIRUSESEPIDEMICSVACCINESDISEASE PREVENTION & CONTROLIMMUNOLOGYTARGETED ASSISTANCESEXUAL BEHAVIORHEALTH IMPACTSCONTRACEPTIVES10.1596/1813-9450-2978